Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats
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چکیده
منابع مشابه
Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...
متن کاملProtective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice
Background Toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. This study investigated the protective effect of thymoquinone (TQ) as a fraction of Nigella sativa on methotrexate (MTX)- induced germ cell apoptosis in male mice. MaterialsAndMethods In this experimental study, thirty male Balb/c mice were divided randomly in...
متن کاملprotective effects of thymoquinone against methotrexate-induced germ cell apoptosis in male mice
background: toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. this study investigated the protective effect of thymoquinone (tq) as a fraction of nigella sativa on methotrexate (mtx)- induced germ cell apoptosis in male mice. materials and methods: in this experimental study, thirty male balb/c mice were divided randoml...
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Background and Aims: Metabolic syndrome, a common metabolic disorder, for the serious health consequences such as insulin resistance and lipid abnormalities has been considered as a major clinical challenge with obscure causes. Oxidative stress is an important component of metabolic syndrome, contributing in its development. Troxerutin, a semi-synthetic derivative of natural bioflavonoid rutin,...
متن کاملN-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes.
Cadmium (Cd) is a reproductive toxicant that induces germ cell apoptosis in the testes. Previous studies have demonstrated that endoplasmic reticulum (ER) stress is involved in Cd-induced germ cell apoptosis. The aim of the present study was to investigate the effects of N-acetylcysteine (NAC), an antioxidant, on Cd-induced ER stress and germ cell apoptosis in the testes. Male CD-1 mice were in...
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ژورنال
عنوان ژورنال: Andrology
سال: 2015
ISSN: 2047-2919
DOI: 10.1111/andr.12036